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Deloitte believes there are four distinct strategic options for banks and credit unions in the future. In two scenarios, an institution remains in control of the customer/member relationship. In the other two, products and distribution become unbundled.

Impaired liver regeneration is associated with reduced cyclin B1 in natural killer T cell-deficient mice.

Ben Ya'acov, Ami; Meir, Hadar; Zolotaryova, Lydia; Ilan, Yaron; Shteyer, Eyal

2017-03-23

It has been shown that the proportion of natural killer T cells is markedly elevated during liver regeneration and their activation under different conditions can modulate this process. As natural killer T cells and liver injury are central in liver regeneration , elucidating their role is important. The aim of the current study is to explore the role of natural killer T cells in impaired liver regeneration . Concanvalin A was injected 4Âdays before partial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-treated mice. Ki-67 and proliferating cell nuclear antigen were used to measure hepatocytes proliferation. Expression of hepatic cyclin B1 and proliferating cell nuclear antigen were evaluated by Western Blot and liver injury was assessed by ALT and histology. Natural killer T cells- deficient or mice injected with anti CD1d antibodies exhibited reduced liver regeneration . These mice were considerably resistant to ConA-induced liver injury. In the absence of NKT cells hepatic proliferating cell nuclear antigen and cyclin B1 decreased in mice injected with Concanvalin A before partial hepatectomy. This was accompanied with reduced serum interleukin-6 levels. Natural killer T cells play an important role in liver regeneration , which is associated with cyclin B1 and interleukin-6.

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Sousa, Dircilei Nascimento de; Santana, Washington Macedo de; Ferreira, Vania Moraes; Duarte, Wagner Rodrigues

To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats , as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae. Surgical procedures were performed in 15 female Wistar rats , 2-month old, to insert the grafting material regenerator (Bone-ceramic®) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery. The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats , except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action. Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.

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